Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment.

Journal article

AIMS: To examine the clinical and biological features of acute lymphoblastic leukaemia in children with Down's syndrome (DS), to compare their survival with other children, and to determine if entry to trials and survival has improved. METHODS: Examination of presenting features and response to treatment in patients treated in two consecutive national trials, MRC UKALL X and XI. RESULTS: The proportion of children with DS was significantly higher in UKALL XI (1.9%) than UKALL X (0.9%). Childr...

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Authors: Chessells, J; Harrison, G; Richards, S; Bailey, C; Hill, F

• Publication status: Published
• Journal: Archives of disease in childhood
• Volume: 85
• Issue: 4
• Pages: 321-325
• Publication date: 2001-10-01
• DOI: 10.1136/adc.85.4.321
• EISSN: 1468-2044
• ISSN: 0003-9888
• Language: English
• Keywords: Infant; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Male; Follow-Up Studies; Cytogenetic Analysis; Disease-Free Survival; Down Syndrome; Chromosome Aberrations; Immunosuppressive Agents; Chromosome Disorders; Survival Rate; Clinical Trials as Topic; Child; Randomized Controlled Trials as Topic; Child, Preschool; Patient Selection; Methotrexate; Female; Humans