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Journal article

Computational analysis of mutations in the transmembrane region of Vpu from HIV-1.

Abstract:

Vpu is an 81 amino acid integral membrane protein encoded by HIV-1. Its alpha-helical transmembrane (TM) domain (residues approximately 6-28) enhances virion release by oligomerizing into bundles and forming ion-conducting channels across the plasma membrane. Its cytoplasmic domain (residues approximately 29-81) is also alpha-helical and binds to the transmembrane protein CD4, inducing its degradation. Mutations within the TM domain have been found to abrogate enhanced particle release from t...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Journal:
Biochimica et biophysica acta
Volume:
1716
Issue:
1
Pages:
1-10
Publication date:
2005-10-01
DOI:
ISSN:
0006-3002
Source identifiers:
100365

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