- Abstract:
-
Vpu is an 81 amino acid integral membrane protein encoded by HIV-1. Its alpha-helical transmembrane (TM) domain (residues approximately 6-28) enhances virion release by oligomerizing into bundles and forming ion-conducting channels across the plasma membrane. Its cytoplasmic domain (residues approximately 29-81) is also alpha-helical and binds to the transmembrane protein CD4, inducing its degradation. Mutations within the TM domain have been found to abrogate enhanced particle release from t...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.bbamem.2005.07.012
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- Journal:
- Biochimica et biophysica acta
- Volume:
- 1716
- Issue:
- 1
- Pages:
- 1-10
- Publication date:
- 2005-10-05
- DOI:
- ISSN:
-
0006-3002
- URN:
-
uuid:11b0f3ba-a0a0-4ff9-a342-211a4d21b016
- Source identifiers:
-
100365
- Local pid:
- pubs:100365
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Computational analysis of mutations in the transmembrane region of Vpu from HIV-1.
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