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Journal article

Comparison of next generation sequencing technologies for the comprehensive assessment of full-length hepatitis C viral genomes

Abstract:

Affordable next generation sequencing (NGS) technologies for hepatitis C virus (HCV) may potentially identify both viral genotype and resistance genetic motifs in the era of directly acting anti-viral (DAA) therapies. This study compared the ability of high-throughput NGS methods to generate full-length, deep, HCV viral sequence datasets and evaluated their utility for diagnostics and clinical assessment.NGS methods using (1) unselected HCV RNA (metagenomic); (2) pre-enrichment of HCV RNA by ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/JCM.00330-16

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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More from this funder
Grant:
090532/Z/09/Z
091663MA
102789/Z/13/Z
National Institute for Health Research More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Clinical Microbiology Journal website
Volume:
54
Issue:
10
Pages:
2470-2484
Publication date:
2016-07-06
Acceptance date:
2016-06-28
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
Source identifiers:
631896
Pubs id:
pubs:631896
UUID:
uuid:11a2d9c8-3203-4444-81e8-9ccc67ddc061
Local pid:
pubs:631896
Deposit date:
2016-07-05

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