Journal article
Comparison of next generation sequencing technologies for the comprehensive assessment of full-length hepatitis C viral genomes
- Abstract:
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Affordable next generation sequencing (NGS) technologies for hepatitis C virus (HCV) may potentially identify both viral genotype and resistance genetic motifs in the era of directly acting anti-viral (DAA) therapies. This study compared the ability of high-throughput NGS methods to generate full-length, deep, HCV viral sequence datasets and evaluated their utility for diagnostics and clinical assessment.NGS methods using (1) unselected HCV RNA (metagenomic); (2) pre-enrichment of HCV RNA by ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 771.4KB)
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(Version of record, pdf, 1.4MB)
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- Publisher copy:
- 10.1128/JCM.00330-16
Authors
Funding
National Institute for Health Research
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Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Journal of Clinical Microbiology Journal website
- Volume:
- 54
- Issue:
- 10
- Pages:
- 2470-2484
- Publication date:
- 2016-07-06
- Acceptance date:
- 2016-06-28
- DOI:
- EISSN:
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1098-660X
- ISSN:
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0095-1137
Item Description
- Pubs id:
-
pubs:631896
- UUID:
-
uuid:11a2d9c8-3203-4444-81e8-9ccc67ddc061
- Local pid:
- pubs:631896
- Source identifiers:
-
631896
- Deposit date:
- 2016-07-05
Terms of use
- Copyright holder:
- Thomson et al
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Thomson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. The full list of authors and funder information is contained in the article.
- Licence:
- CC Attribution (CC BY)
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