Functional evaluation of novel soluble insulin-like growth factor (IGF)-II-specific ligand traps based on modified domain 11 of the human IGF2 receptor.

Journal article

Ligands transported by the mannose 6-phosphate/insulin-like growth factor (IGF)-II receptor (IGF2R) include IGF-II- and mannose 6-phosphate-modified proteins. Increased extracellular supply of IGF-II, either secondary to loss of the clearance function of IGF2R, loss of IGF binding protein function, or increased IGF2 gene expression, can lead to embryonic overgrowth and cancer promotion. Reduced supply of IGF-II is detrimental to tumor growth, and this suggests that gain of function of IGF-II ...

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Authors: Prince, SN; Foulstone, E; Zaccheo, O; Williams, C; Hassan, A

• Publication status: Published
• Journal: Molecular cancer therapeutics
• Volume: 6
• Issue: 2
• Pages: 607-617
• Publication date: 2007-02-01
• DOI: 10.1158/1535-7163.mct-06-0509
• EISSN: 1538-8514
• ISSN: 1535-7163
• Language: English
• Keywords: Embryo, Nonmammalian; Cell Proliferation; Pichia; Receptor, IGF Type 2; Insulin-Like Growth Factor II; Humans; Protein Binding; Embryo, Mammalian; Blotting, Western; Mice, Knockout; Keratinocytes; Drosophila melanogaster; Fibroblasts; Receptors, Fc; Genetic Vectors; Mice; Thymidine; Ligands; Surface Plasmon Resonance; Receptor, IGF Type 1; Animals