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Stimulation of the subthalamic region at 20Hz slows the development of grip force in Parkinson's disease

Abstract:

Excessive synchronization of basal ganglia neuronal activity at ~ 20 Hz is characteristic of patients with untreated Parkinson's disease (PD). Correlative evidence suggests that this activity may contribute to bradykinesia. Attempts to demonstrate causality through stimulation imposed synchronization at 20. Hz in the region of the subthalamic nucleus (STN) have had limited success. Finger-tapping is slowed by about 8% and only in those PD patients that have a relatively normal baseline perfor...

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Journal:
Experimental Neurology
Volume:
231
Issue:
1
Pages:
91-96
Publication date:
2011-09-01
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
Source identifiers:
172491
Language:
English
Keywords:
Pubs id:
pubs:172491
UUID:
uuid:119031df-1fc8-4043-82ef-62959a94c696
Local pid:
pubs:172491
Deposit date:
2012-12-19

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