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Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors

Abstract:: The discoidin domain receptors (DDRs), DDR1 and DDR2, form a unique subfamily of receptor tyrosine kinases that are activated by the binding of triple-helical collagen. Excessive signaling by DDR1 and DDR2 has been linked to the progression of various human diseases, including fibrosis, atherosclerosis and cancer. We report the inhibition of these unusual receptor tyrosine kinases by the multi-targeted cancer drugs imatinib and ponatinib, as well as the selective type II inhibitor DDR1-IN-1. ...
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APA Style

Canning, P., Tan, L., Chu, K., Lee, S., Gray, N., & Bullock, A. (2014). Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. Journal of Molecular Biology, 426(13), 2457–2470.

MLA Style

Canning, P., et al. “Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors.” Journal of Molecular Biology, vol. 426, no. 13, Academic Press, 2014, pp. 2457–70.

Chicago Style

Canning, P, L Tan, K Chu, S Lee, N Gray, and A Bullock. 2014. “Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors.” Journal of Molecular Biology 426 (13): 2457–70.
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Publisher copy:: 10.1016/j.jmb.2014.04.014

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+ Canning, P More by this author

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+ Tan, L More by this author

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+ Chu, K More by this author

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+ Lee, S More by this author

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Bibliographic Details

Publisher:: Academic Press
Journal:: Journal of Molecular Biology
Volume:: 426
Issue:: 13
Pages:: 2457-2470
Publication date:: 2014-06-26
DOI:: 10.1016/j.jmb.2014.04.014
EISSN:: 1089-8638
ISSN:: 0022-2836

Item Description

Language:: English
Keywords:: drug design

oncology

crystallography

phosphorylation

gleevec
Pubs id:: pubs:470233
UUID:: uuid:1175950c-22bb-4294-9627-bc0c9db69c4b
Local pid:: pubs:470233
Source identifiers:: 470233
Deposit date:: 2014-07-03

Terms of use

Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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