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Human T-cell leukemia virus type 1 envelope glycoprotein gp46 interacts with cell surface heparan sulfate proteoglycans.

Abstract:

The major receptors required for attachment and entry of the human T-cell leukemia virus type 1 (HTLV-1) remain to be identified. Here we demonstrate that a functional, soluble form of the HTLV-1 surface envelope glycoprotein, gp46, fused to an immunoglobulin Fc region (gp46-Fc) binds to heparan sulfate proteoglycans (HSPGs) on mammalian cells. Substantial binding of gp46-Fc to HeLa and Chinese hamster ovary (CHO) K1 cells that express HSPGs was detected, whereas binding to the sister CHO lin...

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Publication status:
Published

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Journal:
Journal of virology
Volume:
77
Issue:
18
Pages:
9922-9930
Publication date:
2003-09-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:1174e3f0-b2f9-4014-8fd5-a3390eb46dd4
Source identifiers:
27464
Local pid:
pubs:27464

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