Clostridium difficile mixed infection and reinfection.

Journal article

Isolates from consecutive Clostridium difficile infection (CDI) fecal samples underwent multilocus sequence typing. Potential reinfections with different genotypes were identified in 88/560 (16%) sample pairs taken 1 to 1,414 days (median, 24; interquartile range [IQR], 1 to 52 days) apart; odds of reinfection increased by 58% for every doubling of time between samples. Of 109 sample pairs taken on the same day, 3 (3%) had different genotypes. Considering samples 0 to 7 days apart as the same CDI, 7% of cases had mixed infections with >1 genotype.

Authors: Eyre, D; Walker, A; Griffiths, D; Wilcox, M; Wyllie, D

• Publication status: Published
• Journal: Journal of clinical microbiology
• Volume: 50
• Issue: 1
• Pages: 142-144
• Publication date: 2012-01-01
• DOI: 10.1128/jcm.05177-11
• EISSN: 1098-660X
• ISSN: 0095-1137
• Language: English
• Keywords: Feces; Humans; Coinfection; Molecular Epidemiology; Genotype; Clostridium difficile; Multilocus Sequence Typing; Clostridium Infections; Recurrence; Cluster Analysis