Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension

Journal article

Mixed treatment comparison (MTC) meta-analyses estimate relative treatment effects from networks of evidence while preserving randomisation. We extend the MTC framework to allow for repeated measurements of a continuous endpoint that varies over time. We used, as a case study, a systematic review and meta-analysis of intraocular pressure (IOP) measurements from randomised controlled trials evaluating topical ocular hypotensives in primary open-angle glaucoma or ocular hypertension because IOP...

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Authors: Dakin, H; Welton, N; Ades, A; Collins, S; Orme, M

• Publication status: Published
• Journal: STATISTICS IN MEDICINE
• Volume: 30
• Issue: 20
• Pages: 2511-2535
• Publication date: 2011-09-10
• DOI: 10.1002/sim.4284
• EISSN: 1097-0258
• ISSN: 0277-6715
• Language: English
• Keywords: mixed treatment comparison meta-analysis; primary open-angle glaucoma; ocular hypertension; panel data; network meta-analysis; meta-regression