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Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids.

Abstract:

In most gram-negative bacteria, acquired multiresistance is conferred by large plasmids compiling numerous antimicrobial resistance genes. Here, we show an evolutionary alternative strategy used by Pasteurella multocida to become resistant to multiple clinically relevant antibiotics. Thirteen beta-lactam-resistant clinical isolates, concomitantly resistant to tetracyclines and/or streptomycin as well as to sulfonamides, were studied. Pulsed-field gel electrophoresis analysis revealed differen...

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Publisher copy:
10.1128/aac.01522-08

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Journal:
Antimicrobial agents and chemotherapy More from this journal
Volume:
53
Issue:
8
Pages:
3399-3404
Publication date:
2009-08-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Language:
English
Keywords:
Pubs id:
pubs:386893
UUID:
uuid:116dc1f1-8fc7-4271-aac7-d384b8c66a21
Local pid:
pubs:386893
Source identifiers:
386893
Deposit date:
2013-11-16

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