Journal article
Reversible energy-transfer switching on a DNA scaffold
- Abstract:
- We show that FRET between Pacific Blue (PB) and Alexa488 (A488) covalently attached to a DNA scaffold can be reversibly controlled by photochromic switching of a spiropyran derivative. With the spiropyran in the closed spiro isomeric form, FRET occurs freely between PB and A488. UV-induced isomerization to the open merocyanine form shuts down the FRET process by efficient quenching of the PB excited state. The process is reversed by exposure to visible light, triggering the isomerization to the spiro isomer.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 512.3KB, Terms of use)
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(Preview, Supplementary materials, pdf, 367.1KB, Terms of use)
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- Publisher copy:
- 10.1021/ja512416n
Authors
+ Biotechnology and Biological Sciences Research Council
More from this funder
- Grant:
- sLOLAgrant BB/J001694/1 “extending the boundaries of nucleic acidchemistry”
- Publisher:
- American Chemical Society
- Journal:
- Journal of the American Chemical Society More from this journal
- Volume:
- 137
- Issue:
- 7
- Pages:
- 2444-2447
- Publication date:
- 2015-02-17
- DOI:
- EISSN:
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1520-5126
- ISSN:
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0002-7863
- Language:
-
English
- Pubs id:
-
pubs:509742
- UUID:
-
uuid:116bbb3a-cde8-4e13-bf52-b250dbc2777e
- Local pid:
-
pubs:509742
- Source identifiers:
-
509742
- Deposit date:
-
2016-03-01
- ARK identifier:
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2015
- Rights statement:
- Copyright © 2015 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
- Licence:
- Other
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