Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold.

Journal article

A potential anti-HIV and HCV drug candidate is highly desirable as coinfection has become a worldwide public health challenge. A potent compound based on a tetrabutoxy-calix[4]arene scaffold that possesses dual inhibition for both HIV and HCV is described. Structural activity relationship studies demonstrate the effects of lower-rim alkylation in maintaining cone conformation and upper-rim interacting head groups on the calix[4]arene play key roles for its potent dual antiviral activities.

Authors: Tsou, L; Dutschman, G; Gullen, E; Telpoukhovskaia, M; Cheng, Y

• Publication status: Published
• Journal: Bioorganic and medicinal chemistry letters
• Volume: 20
• Issue: 7
• Pages: 2137-2139
• Publication date: 2010-04-01
• DOI: 10.1016/j.bmcl.2010.02.043
• EISSN: 1464-3405
• ISSN: 0960-894X
• Language: English
• Keywords: Inhibitory Concentration 50; Antiviral Agents; Molecular Structure; HIV; HIV Infections; Cell Survival; Hepatitis C; Calixarenes; Models, Molecular; Hepacivirus; Cell Line