Journal article
Action initiation shapes mesolimbic dopamine encoding of future rewards
- Abstract:
- It is widely held that dopamine signaling encodes predictions of future rewards and such predictions are regularly used to drive behavior, but the relationship between these two is poorly defined. We found in rats that nucleus accumbens dopamine following a reward-predicting cue was attenuated unless movement was correctly initiated. Our results indicate that dopamine release in this region is contingent on correct action initiation and not just reward prediction.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 291.0KB, Terms of use)
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(Preview, Supplementary materials, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1038/nn.4187
Authors
+ Medical Research Council
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- Grant:
- MC_UU_12020/5
- MC_UU_12024/2
- MC_UU_12024/5
- MC_UU_12024/1
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Neuroscience More from this journal
- Volume:
- 19
- Issue:
- 1
- Pages:
- 34–36
- Publication date:
- 2016-12-07
- Acceptance date:
- 2016-11-04
- DOI:
- ISSN:
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1546-1726
- Language:
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English
- Pubs id:
-
pubs:579368
- UUID:
-
uuid:115b6f41-ea6b-416a-b309-062874c429e8
- Local pid:
-
pubs:579368
- Source identifiers:
-
579368
- Deposit date:
-
2015-12-11
- ARK identifier:
Terms of use
- Copyright holder:
- Nature America, Inc.
- Copyright date:
- 2015
- Rights statement:
- © 2016 Nature America, Inc.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at https://dx.doi.org/10.1038/nn.4187
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