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Action initiation shapes mesolimbic dopamine encoding of future rewards

Abstract:
It is widely held that dopamine signaling encodes predictions of future rewards and such predictions are regularly used to drive behavior, but the relationship between these two is poorly defined. We found in rats that nucleus accumbens dopamine following a reward-predicting cue was attenuated unless movement was correctly initiated. Our results indicate that dopamine release in this region is contingent on correct action initiation and not just reward prediction.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nn.4187

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
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Grant:
MC_UU_12020/5; MC_UU_12024/2; MC_UU_12024/5; MC_UU_12024/1
Economic and Social Research Council More from this funder
St John's College, Oxford More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Neuroscience Journal website
Volume:
19
Pages:
34–36
Publication date:
2016-01-01
DOI:
ISSN:
1546-1726
URN:
uuid:115b6f41-ea6b-416a-b309-062874c429e8
Source identifiers:
579368
Local pid:
pubs:579368

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