Inhibition of dendropoiesis by tumor derived and purified prostate specific antigen.

Journal article

PURPOSE: Prostate specific antigen (PSA) is a serine protease produced by the prostate gland at high concentrations. Serum PSA may be significantly elevated in prostate cancer and benign prostatic diseases. It has recently become evident that, in addition to being a tissue and/or serum marker, PSA may also have biological effects. Despite the voluminous literature on this biomarker in the diagnosis of prostatic diseases relatively few reports have addressed the issue of the physiological fun...

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Authors: Aalamian, M; Tourkova, I; Chatta, G; Lilja, H; Huland, E

• Journal: Journal of urology
• Volume: 170
• Issue: 5
• Pages: 2026-2030
• Publication date: 2003-11-01
• DOI: 10.1097/01.ju.0000091264.46134.b7
• EISSN: 1527-3792
• ISSN: 0022-5347
• Language: English
• Keywords: T-Lymphocytes; Prostate-Specific Antigen; Cell Differentiation; Prostatic Neoplasms; Dendritic Cells; Tumor Cells, Cultured; Mice; Male; Lymphocyte Activation; Humans; Tumor Escape; Animals; Lymphocyte Culture Test, Mixed; Immune Tolerance