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Inactivation and activity of cholesterol-dependent cytolysins: what structural studies tell us.

Abstract:

The homologous bacterially expressed cholesterol-dependent cytolysins (CDCs) form pores via oligomerization; this must occur preferentially once the target membrane has been engaged. Conformational changes in CDCs then drive partition from an aqueous environment to a lipidic one. This review addresses how premature oligomerization is prevented, how conformational changes are triggered, and how cooperativity between subunits brings about new functionality absent from isolated protomers. Variat...

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Publisher copy:
10.1016/j.str.2005.04.019

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Structure (London, England : 1993)
Volume:
13
Issue:
8
Pages:
1097-1106
Publication date:
2005-08-01
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Source identifiers:
7699
Language:
English
Keywords:
Pubs id:
pubs:7699
UUID:
uuid:115296b6-ea13-4e5c-b679-95dcb0b04a39
Local pid:
pubs:7699
Deposit date:
2012-12-19

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