- Abstract:
-
The homologous bacterially expressed cholesterol-dependent cytolysins (CDCs) form pores via oligomerization; this must occur preferentially once the target membrane has been engaged. Conformational changes in CDCs then drive partition from an aqueous environment to a lipidic one. This review addresses how premature oligomerization is prevented, how conformational changes are triggered, and how cooperativity between subunits brings about new functionality absent from isolated protomers. Variat...
Expand abstract - Publisher copy:
- 10.1016/j.str.2005.04.019
-
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- Journal:
- Structure (London, England : 1993)
- Volume:
- 13
- Issue:
- 8
- Pages:
- 1097-1106
- Publication date:
- 2005-08-05
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- URN:
-
uuid:115296b6-ea13-4e5c-b679-95dcb0b04a39
- Source identifiers:
-
7699
- Local pid:
- pubs:7699
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Inactivation and activity of cholesterol-dependent cytolysins: what structural studies tell us.
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