Journal article
Inactivation and activity of cholesterol-dependent cytolysins: what structural studies tell us.
- Abstract:
-
The homologous bacterially expressed cholesterol-dependent cytolysins (CDCs) form pores via oligomerization; this must occur preferentially once the target membrane has been engaged. Conformational changes in CDCs then drive partition from an aqueous environment to a lipidic one. This review addresses how premature oligomerization is prevented, how conformational changes are triggered, and how cooperativity between subunits brings about new functionality absent from isolated protomers. Variat...
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- Publisher copy:
- 10.1016/j.str.2005.04.019
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Authors
Bibliographic Details
- Journal:
- Structure (London, England : 1993)
- Volume:
- 13
- Issue:
- 8
- Pages:
- 1097-1106
- Publication date:
- 2005-08-01
- DOI:
- EISSN:
-
1878-4186
- ISSN:
-
0969-2126
- Source identifiers:
-
7699
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:7699
- UUID:
-
uuid:115296b6-ea13-4e5c-b679-95dcb0b04a39
- Local pid:
- pubs:7699
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2005
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