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Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial

Abstract:

Previous preclinical research has shown that extracorporeal devices can be used to enhance the delivery and distribution of systemically administered anticancer drugs, resulting in increased intratumoural concentrations. We aimed to assess the safety and feasibility of targeted release and enhanced delivery of doxorubicin to solid tumours from thermosensitive liposomes triggered by mild hyperthermia, induced non-invasively by focused ultrasound.We did an open-label, single-centre, phase 1 tri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/s1470-2045(18)30332-2

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
ORCID:
0000-0002-8432-5771
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet Oncology Journal website
Volume:
19
Issue:
8
Pages:
1027-1039
Publication date:
2018-07-11
Acceptance date:
2018-04-20
DOI:
EISSN:
1470-2045
ISSN:
1474-5488
Pmid:
30001990
Source identifiers:
889877
Language:
English
Keywords:
Pubs id:
pubs:889877
UUID:
uuid:114c2816-9ca6-49a3-aeea-003f942e8ac1
Local pid:
pubs:889877
Deposit date:
2018-07-23

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