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Neutron and X-ray scattering studies on the human complement protein properdin provide an analysis of the thrombospondin repeat.

Abstract:

Properdin is a regulatory glycoprotein of the alternative pathway of the complement system of immune defense. It is responsible for the stabilization of the C3 convertase complex formed between C3b and the Bb fragment of factor B. Neutron and X-ray solution scattering experiments were performed on the dimeric and trimeric forms of properdin. These have RG values of 9.1 and 10.7 nm, respectively. The scattering curves were compared with Debye sphere modeling simulations for properdin. Good agr...

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Publication status:
Published

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Publisher copy:
10.1021/bi00246a018

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Perkins, SJ More by this author
Journal:
Biochemistry
Volume:
30
Issue:
32
Pages:
8000-8008
Publication date:
1991-08-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:114949b2-7fa1-4000-9e0d-c0f6643f57f8
Source identifiers:
58424
Local pid:
pubs:58424

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