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Partial reduction of electron-deficient pyridines

Abstract:
The partial reduction of electron-deficient pyridines is described herein. Mono- and disubstituted pyridines can be transformed into functionalized dihydropyridines using either Birch reduction conditions or sodium/naphthalene in THF. The compounds formed by these high-yielding reductive alkylation protocols have potential as synthetic intermediates, and we have shown that bicyclo compounds containing 6,5, 6,6, and 6,7 ring systems can be prepared in one step via a base-promoted cylization.
Publication status:
Published

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Publisher copy:
10.1021/ol0065930

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Organic letters
Volume:
2
Issue:
24
Pages:
3861-3863
Publication date:
2000-11-05
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
URN:
uuid:11372ce7-44b8-4bc2-8781-4d20a5aebc95
Source identifiers:
31787
Local pid:
pubs:31787
Language:
English

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