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Modelling sequential protein folding under kinetic control

Abstract:

Motivation: This study presents a novel investigation of the effect of kinetic control on cotranslational protein folding. We demonstrate the effect using simple HP lattice models and show that the cotranslational folding of proteins under kinetic control has significant impact on the final conformation. Differences arise if nature is not capable of pushing a partially folded protein back over a large energy barrier. For this reason we argue that such constraints should be incorporated into s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/bioinformatics/btl248

Authors


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Institution:
Macquarie University, NSW, Australia
Department:
Department of Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Research group:
Oxford Protein Informatics Group
Role:
Author
More by this author
Institution:
Macquarie University, NSW, Australia
Department:
Department of Statistics
Role:
Author
Publisher:
Oxford University Press Publisher's website
Journal:
Bioinformatics Journal website
Volume:
22
Issue:
14
Pages:
e203-e210
Publication date:
2006-07-01
DOI:
EISSN:
1460-2059
ISSN:
1367-4803

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