Motivation: This study presents a novel investigation of the effect of kinetic control on cotranslational protein folding. We demonstrate the effect using simple HP lattice models and show that the cotranslational folding of proteins under kinetic control has significant impact on the final conformation. Differences arise if nature is not capable of pushing a partially folded protein back over a large energy barrier. For this reason we argue that such constraints should be incorporated into s...Expand abstract
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- Peer reviewed
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- Fabien P. E. Huard et al.
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- The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact firstname.lastname@example.org. Citation: Huard, F. P. E. et al. (2006). 'Modelling sequential protein folding under kinetic control', Bioinformatics, 22(14), e203-e210. [Available at http://bioinformatics.oxfordjournals.org/cgi/content/abstract/22/14/e203].
Modelling sequential protein folding under kinetic control
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