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GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women.

Abstract:

OBJECTIVE: Lumbar disc degeneration (LDD) is a serious social and medical problem which has been shown to be highly heritable. It has similarities with peripheral joint osteoarthritis (OA) in terms of both epidemiology and pathologic processes. A few known genetic variants have been identified using a candidate gene approach, but many more are thought to exist. GDF5 is a gene whose variants have been shown to play a role in skeletal height as well as predisposing to peripheral joint OA. In vi...

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Publisher copy:
10.1002/art.30169

Authors


Williams, FM More by this author
de Schepper, E More by this author
Bierma-Zeinstra, S More by this author
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Journal:
Arthritis and rheumatism
Volume:
63
Issue:
3
Pages:
708-712
Publication date:
2011-03-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:1123b104-9d7d-4ed6-934d-d7af2520a600
Source identifiers:
126392
Local pid:
pubs:126392

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