Platelet-induced autoagglutination of Plasmodium falciparum-infected red blood cells and disease severity in Thailand.

Journal article

The relationship of the platelet-mediated autoagglutination of Plasmodium falciparum-infected red blood cells (IRBCs) to disease severity was investigated in 182 Thai patients with falciparum malaria; it was evident in 43% of uncomplicated malaria (n=63), 41% of severe malaria (n=104), and 100% of cerebral malaria (n=15; P=.001) isolates. The median (range) number of IRBCs in agglutinates per 1000 IRBCs was significantly higher in cerebral malaria (6 [3-42]) than in severe (0 [0-52]) and uncomplicated (0 [0-24]) malaria (P=.01). In multivariate analyses, high parasitemia and cerebral malaria were associated independently with parasite agglutination.

Authors: Chotivanich, K; Sritabal, J; Udomsangpetch, R; Newton, P; Stepniewska, K

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 189
• Issue: 6
• Pages: 1052-1055
• Publication date: 2004-03-01
• DOI: 10.1086/381900
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Antigens, CD36; Malaria, Falciparum; Erythrocytes; Erythrocyte Aggregation; Severity of Illness Index; Agglutination; Rosette Formation; Blood Platelets; Adult; Humans