- Abstract:
-
BACKGROUND: Exposure to food allergens through a disrupted skin barrier has been recognized as a potential factor in the increasing prevalence of food allergy. OBJECTIVE: We sought to test the immunologic mechanisms by which epicutaneous sensitization to food allergens predisposes to intestinal food allergy. METHODS: Mice were epicutaneously sensitized with ovalbumin or peanut on an atopic dermatitis-like skin lesion, followed by intragastric antigen challenge. Antigen-specific serum IgE leve...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jaci.2014.01.021
-
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- Journal:
- The Journal of allergy and clinical immunology
- Volume:
- 133
- Issue:
- 5
- Pages:
- 1390-1399.e6
- Publication date:
- 2014-05-05
- DOI:
- EISSN:
-
1097-6825
- ISSN:
-
0091-6749
- URN:
-
uuid:111ae041-cf60-4097-8239-3e249223bd3a
- Source identifiers:
-
451133
- Local pid:
- pubs:451133
- Language:
- English
- Keywords:
- Copyright date:
- 2014
Journal article
Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis.
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