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Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis.

Abstract:

BACKGROUND: Exposure to food allergens through a disrupted skin barrier has been recognized as a potential factor in the increasing prevalence of food allergy. OBJECTIVE: We sought to test the immunologic mechanisms by which epicutaneous sensitization to food allergens predisposes to intestinal food allergy. METHODS: Mice were epicutaneously sensitized with ovalbumin or peanut on an atopic dermatitis-like skin lesion, followed by intragastric antigen challenge. Antigen-specific serum IgE leve...

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Publication status:
Published

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Publisher copy:
10.1016/j.jaci.2014.01.021

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Journal:
The Journal of allergy and clinical immunology
Volume:
133
Issue:
5
Pages:
1390-1399.e6
Publication date:
2014-05-05
DOI:
EISSN:
1097-6825
ISSN:
0091-6749
URN:
uuid:111ae041-cf60-4097-8239-3e249223bd3a
Source identifiers:
451133
Local pid:
pubs:451133

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