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VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm.

Abstract:

During development, the axons of retinal ganglion cell (RGC) neurons must decide whether to cross or avoid the midline at the optic chiasm to project to targets on both sides of the brain. By combining genetic analyses with in vitro assays, we show that neuropilin 1 (NRP1) promotes contralateral RGC projection in mammals. Unexpectedly, the NRP1 ligand involved is not an axon guidance cue of the class 3 semaphorin family, but VEGF164, the neuropilin-binding isoform of the classical vascular gr...

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Authors


Erskine, L More by this author
Reijntjes, S More by this author
Schwarz, Q More by this author
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Journal:
Neuron
Volume:
70
Issue:
5
Pages:
951-965
Publication date:
2011-06-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:1117c03b-1dd1-4cb4-839f-57bd95c6facb
Source identifiers:
428923
Local pid:
pubs:428923

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