Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of shaker-type-potassium channels (Kv1 channels) within the nodal complex of myelinated axons following injury. At the neuroma that forms after damage, expression of Kv1.1 and 1.2 (normally localised to the juxtaparanode) was markedly decreased. In contrast Kv1.4 and 1.6, which were ha...Expand abstract
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- Peer reviewed
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- Calvo et al.
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- © 2016, Calvo et al. This article is distributed under the terms of the Creative Commons Attribution License.
Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury
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