- Abstract:
-
BACKGROUND: The detection of insulin autoantibodies (IAA) aids in the prediction of autoimmune diabetes development. However, the long-standing, gold standard 125I-insulin radiobinding assay (RBA) has low reproducibility between laboratories, long sample processing times and requires the use of newly synthesized radiolabeled insulin for each set of assays. Therefore, a rapid, non-radioactive, and reproducible assay is highly desirable. METHODS: We have developed electrochemiluminescence (ECL...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1186/1479-5876-9-203
-
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- Journal:
- Journal of translational medicine
- Volume:
- 9
- Issue:
- 1
- Pages:
- 203
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1479-5876
- ISSN:
-
1479-5876
- URN:
-
uuid:10f676da-4c07-48a1-9ce2-9b8443723859
- Source identifiers:
-
445329
- Local pid:
- pubs:445329
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status.
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