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Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status.

Abstract:

BACKGROUND: The detection of insulin autoantibodies (IAA) aids in the prediction of autoimmune diabetes development. However, the long-standing, gold standard 125I-insulin radiobinding assay (RBA) has low reproducibility between laboratories, long sample processing times and requires the use of newly synthesized radiolabeled insulin for each set of assays. Therefore, a rapid, non-radioactive, and reproducible assay is highly desirable. METHODS: We have developed electrochemiluminescence (ECL...

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Publication status:
Published

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Publisher copy:
10.1186/1479-5876-9-203

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Journal:
Journal of translational medicine
Volume:
9
Issue:
1
Pages:
203
Publication date:
2011-01-01
DOI:
EISSN:
1479-5876
ISSN:
1479-5876
URN:
uuid:10f676da-4c07-48a1-9ce2-9b8443723859
Source identifiers:
445329
Local pid:
pubs:445329

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