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Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption.

Abstract:

Targeted disruption of the epididymis-specific HE6/Gpr64 receptor gene in mice led to male infertility. In order to characterize the phenotype at a molecular level, we compared the gene expression patterns of wild type (wt) versus knockout (KO) caput epididymides. The caput region of KO males, although morphologically normal, nevertheless showed an aberrant expression pattern. Combining micro array analysis, differential library screening, Northern blot analysis and quantitative RT-PCR, we fo...

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Publisher copy:
10.1002/mrd.20636

Authors


Cappallo-Obermann, H More by this author
Spiess, AN More by this author
Theuring, F More by this author
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Journal:
Molecular reproduction and development
Volume:
74
Issue:
5
Pages:
539-553
Publication date:
2007-05-05
DOI:
EISSN:
1098-2795
ISSN:
1040-452X
URN:
uuid:10f6760e-65e5-4e33-ac85-0523ee802065
Source identifiers:
95886
Local pid:
pubs:95886

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