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Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.

Abstract:

The netrin-like (NTR) domain is a feature of several extracellular proteins, most notably the N-terminal domain of tissue inhibitors of metalloproteinases (TIMPs), where it functions as a strong inhibitor of matrix metalloproteinases and some other members of the metzincin superfamily. The presence of a C-terminal NTR domain in procollagen C-proteinase enhancers (PCPEs), proteins that stimulate the activity of astacin-like tolloid proteinases, raises the possibility that this might also have ...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m109.086447

Authors


Bekhouche, M More by this author
Kronenberg, D More by this author
Vadon-Le Goff, S More by this author
Bijakowski, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
The Journal of biological chemistry
Volume:
285
Issue:
21
Pages:
15950-15959
Publication date:
2010-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:10e51ad1-67c4-4a12-8305-527166a4665b
Source identifiers:
227269
Local pid:
pubs:227269

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