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Challenge of investigating biologically relevant functions of virulence factors in bacterial pathogens.

Abstract:

Recent innovations have increased enormously the opportunities for investigating the molecular basis of bacterial pathogenicity, including the availability of whole-genome sequences, techniques for identifying key virulence genes, and the use of microarrays and proteomics. These methods should provide powerful tools for analysing the patterns of gene expression and function required for investigating host-microbe interactions in vivo. But, the challenge is exacting. Pathogenicity is a complex...

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Publisher copy:
10.1098/rstb.2000.0605

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
355
Issue:
1397
Pages:
643-656
Publication date:
2000-05-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:10e4c5d4-a854-4e73-af18-9a65b5113750
Source identifiers:
246198
Local pid:
pubs:246198

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