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Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications.

Abstract:

Atherosclerosis is the pathological process that underlies the development of cardiovascular disease, a leading cause of mortality. Atherosclerotic plaque formation is driven by the recruitment of inflammatory monocytes into the artery wall, their differentiation into macrophages and the subsequent transformation of macrophages into cholesterol-laden foam cells. Models of hypercholesterolaemia such as the ApoE (apolipoprotein E)-/- mouse and the application of transgenic technologies have all...

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Publication status:
Published

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Publisher copy:
10.1042/cs20090488

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Clinical science (London, England : 1979)
Volume:
118
Issue:
11
Pages:
641-655
Publication date:
2010-06-01
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
Source identifiers:
50310
Language:
English
Keywords:
Pubs id:
pubs:50310
UUID:
uuid:10dcd30d-85f9-4c08-b321-6e982f285186
Local pid:
pubs:50310
Deposit date:
2012-12-19

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