Is B cell tolerance essential for transplantation tolerance?

Journal article

In some transplantation settings, achieving B cell as well as T cell tolerance will be essential in order to ensure long-term graft survival. However, in other situations, although B cell tolerance could potentially offer advantages to the long-term function of the graft and may therefore be desirable, there is no evidence that inducing B cell tolerance alongside T cell tolerance is essential. This overview forms part of a debate discussing the potential role of B cell tolerance in transplantation and uses selected examples in the literature to address the question: is B cell tolerance essential for transplantation tolerance?

Authors: Wood, K

• Publication status: Published
• Journal: Transplantation
• Volume: 79
• Issue: 3 Suppl
• Pages: S40-S42
• Publication date: 2005-02-01
• DOI: 10.1097/01.tp.0000153300.22231.a1
• EISSN: 1534-6080
• ISSN: 0041-1337
• Language: English
• Keywords: Acute Disease; Humans; Transplantation Immunology; B-Lymphocytes; Animals; Graft Rejection; Antibody Formation; Transplantation, Homologous; Immune Tolerance; T-Lymphocytes