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Persistence of atovaquone in human sera following treatment: inhibition of Plasmodium falciparum development in vivo and in vitro.

Abstract:

Published pharmacokinetic data indicate that after treatment of patients with therapeutic doses of atovaquone/proguanil hydrochloride (Malarone, GlaxoSmithKline Research Triangle Park, NC), the plasma half-lives of these drugs are 70h and 15h, respectively. However, using two biologic assays (mosquito transmission and in vitro asexual stage development), we demonstrate here that sera from volunteers treated with atovaquone/proguanil retained activity against Plasmodium falciparum up to 6 week...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
American journal of tropical medicine and hygiene
Volume:
68
Issue:
1
Pages:
111-114
Publication date:
2003-01-01
EISSN:
1476-1645
ISSN:
0002-9637
Source identifiers:
273347
Language:
English
Keywords:
Pubs id:
pubs:273347
UUID:
uuid:10d73a7f-b4cc-4ae2-9fbb-40d9a92e4418
Local pid:
pubs:273347
Deposit date:
2012-12-19

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