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NMR structure of the KaiC-interacting C-terminal domain of KaiA, a circadian clock protein: implications for KaiA-KaiC interaction.

Abstract:

KaiA is a two-domain circadian clock protein in cyanobacteria, acting as the positive element in a feedback loop that sustains the oscillation. The structure of the N-terminal domain of KaiA is that of a pseudo-receiver, similar to those of bacterial response regulators, which likely interacts with components of the clock-resetting pathway. The C-terminal domain of KaiA is highly conserved among cyanobacteria and enhances the autokinase activity of KaiC. Here we present the NMR structure of t...

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Publisher copy:
10.1073/pnas.0305516101

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
6
Pages:
1479-1484
Publication date:
2004-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:10d72c57-750a-4d16-a12c-1b260eaf1281
Source identifiers:
196791
Local pid:
pubs:196791

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