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The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice.

Abstract:

The functional role of invariant chain in T-cell selection events and antigen presentation is well established. The invariant chain gene encodes differentially spliced isoforms, Ii31 and Ii41. The Ii41 isoform has been described to increase the efficiency of antigen presentation. We have analysed the effect of the Ii41 isoform on positive and negative selection of transgenic CD4 T cells with specificity for a natural self antigen (C5) which are crucially dependent on invariant chain for their...

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Publication status:
Published

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Authors


Wright, RJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Stockinger, B More by this author
Journal:
Immunology
Volume:
95
Issue:
3
Pages:
309-313
Publication date:
1998-11-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:10d1d0cd-5f36-45c4-b451-305af8cf22df
Source identifiers:
30511
Local pid:
pubs:30511

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