Journal article
Assessing the causal association of glycine with risk of cardio-metabolic diseases
- Abstract:
- Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine plays an aetiological role. We present a meta-analysis of genome-wide association studies for glycine in 80,003 participants and investigate the causality and potential mechanisms of the association between glycine and cardio-metabolic diseases using genetic approaches. We identify 27 genetic loci, of which 22 have not previously been reported for glycine. We show that glycine is genetically associated with lower CHD risk and find that this may be partly driven by blood pressure. Evidence for a genetic association of glycine with T2D is weaker, but we find a strong inverse genetic effect of hyperinsulinaemia on glycine. Our findings strengthen evidence for a protective effect of glycine on CHD and show that the glycine-T2D association may be driven by a glycine-lowering effect of insulin resistance.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-019-08936-1
Authors
- Publisher:
- Nature Research
- Journal:
- Nature Communications More from this journal
- Volume:
- 10
- Issue:
- 1
- Article number:
- 1060
- Publication date:
- 2019-03-05
- Acceptance date:
- 2019-02-01
- DOI:
- ISSN:
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2041-1723
- Pmid:
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30837465
- Language:
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English
- Pubs id:
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pubs:980333
- UUID:
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uuid:10ce9c01-a3d4-45f0-8ca9-d1c497a96f1b
- Local pid:
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pubs:980333
- Source identifiers:
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980333
- Deposit date:
-
2019-03-12
Terms of use
- Copyright holder:
- Wittemans et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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