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Glycodendriproteins: a synthetic glycoprotein mimic enzyme with branched sugar-display potently inhibits bacterial aggregation.

Abstract:

The continuing ability of bacteria to resist current antibiotic treatments highlights the need for alternative strategies for inhibiting their pathogenicity. Bacterial attachment is a major factor in infectivity and virulence. This key binding phase of bacteria to any potential host is mediated by adhesin proteins and so these present an attractive therapeutic target for antiinfective blocking strategies. However, the natural ligands to adhesins are large, typically complex molecules that are...

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Publication status:
Published

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Publisher copy:
10.1021/ja031698u

Authors


Rendle, PM More by this author
Rodrigues, J More by this author
Oldham, NJ More by this author
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Journal:
Journal of the American Chemical Society
Volume:
126
Issue:
15
Pages:
4750-4751
Publication date:
2004-04-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:10c624f8-1778-4639-9210-a6f7551706ca
Source identifiers:
32681
Local pid:
pubs:32681

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