- Abstract:
-
alpha-Synuclein is a pre-synaptic protein, the function of which is not completely understood, but its pathological form is involved in neurodegenerative diseases. In vitro, alpha-synuclein spontaneously forms amyloid fibrils. Here, we report that alphaB-crystallin, a molecular chaperone found in Lewy bodies that are characteristic of Parkinson's disease (PD), is a potent in vitro inhibitor of alpha-synuclein fibrillization, both of wild-type and the two mutant forms (A30P and A53T) that caus...
Expand abstract - Publisher copy:
- 10.1016/j.jmb.2004.05.054
-
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- Journal:
- Journal of molecular biology
- Volume:
- 340
- Issue:
- 5
- Pages:
- 1167-1183
- Publication date:
- 2004-07-05
- DOI:
- EISSN:
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1089-8638
- ISSN:
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0022-2836
- URN:
-
uuid:10c0116f-9c35-445c-a614-fad87a7abf7b
- Source identifiers:
-
60300
- Local pid:
- pubs:60300
- Copyright date:
- 2004
Journal article
Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity.
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