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A Golgi localization signal identified in the Menkes recombinant protein.

Abstract:

Menkes disease arises from a genetic impairment in copper transport. The gene responsible for the phenotype has been identified as a copper transporting ATPase ( ATP7A ). Recently, the protein encoded by the ATP7A gene has been localized to the Golgi complex. In order to investigate the role of the Menkes disease protein in copper transport, recombinant constructs containing both the full-length open reading frame and an alternatively spliced form have been successfully expressed and localize...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/7.8.1245

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Journal:
Human molecular genetics
Volume:
7
Issue:
8
Pages:
1245-1252
Publication date:
1998-08-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:10ae68f6-fbc8-4ed1-8437-73eacbfc0342
Source identifiers:
36203
Local pid:
pubs:36203

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