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Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos.

Abstract:

A common feature of development in most vertebrate models is the early segregation of the germ line from the soma. For example, in Xenopus and zebrafish embryos primordial germ cells (PGCs) are specified by germ plasm that is inherited from the egg; in mice, Blimp1 expression in the epiblast mediates the commitment of cells to the germ line. How these disparate mechanisms of PGC specification evolved is unknown. Here, in order to identify the ancestral mechanism of PGC specification in verteb...

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Publication status:
Published

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Publisher copy:
10.1242/dev.105346

Authors


Chatfield, J More by this author
O'Reilly, MA More by this author
Bachvarova, RF More by this author
Ferjentsik, Z More by this author
Redwood, C More by this author
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Publisher:
Company of Biologists Ltd
Journal:
Development (Cambridge, England)
Volume:
141
Issue:
12
Pages:
2429-2440
Publication date:
2014-06-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:10a2dca3-968c-47d3-b828-cdbd52e41c09
Source identifiers:
469557
Local pid:
pubs:469557

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