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A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor.

Abstract:

The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the 'Cys-loop' superfamily of ligand-gated ion channels which mediate synaptic neurotransmission, and whose other members include receptors for glycine, gamma-aminobutyric acid and serotonin. Cryo-electron microscopy has yielded a three-dimensional structure of the nAChR in its closed state. However, the exact nature and location of the channel gate remains uncertain. Although the transmembrane pore is constricted close ...

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Publication status:
Published

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Publisher copy:
10.1088/1478-3975/3/2/007

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Journal:
Physical biology
Volume:
3
Issue:
2
Pages:
147-159
Publication date:
2006-06-01
DOI:
EISSN:
1478-3975
ISSN:
1478-3967
Source identifiers:
100879
Language:
English
Keywords:
Pubs id:
pubs:100879
UUID:
uuid:1095af4e-c909-4200-93b8-7f8b4f81e2f0
Local pid:
pubs:100879
Deposit date:
2012-12-19

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