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Combined effects of fibrinogen genetic variability on atherosclerosis in patients with or without stable angina pectoris: Focus on the coagulation cascade and endothelial function

Abstract:

Background Fibrinogen is a coagulation/inflammatory biomarker strongly associated with atherogenesis. Data have reported that the genetic variability on fibrinogen chains may affect the atherosclerotic process and the risk of coronary artery disease (CAD). We examined the combined effects of the G455A and the G58A fibrinogen genetic polymorphisms on prothrombotic profile, endothelial function and the risk of CAD in a Caucasian population. Methods We recruited 422 patients with angiographicall...

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Authors


Papageorgiou, N More by this author
Tousoulis, D More by this author
Kozanitou, M More by this author
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Journal:
International Journal of Cardiology
Volume:
168
Issue:
5
Pages:
4602-4607
Publication date:
2013-10-12
DOI:
EISSN:
1874-1754
ISSN:
0167-5273
URN:
uuid:108bb516-29d3-44e2-bfe5-fdc70fcea75b
Source identifiers:
439236
Local pid:
pubs:439236

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