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Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension.

Abstract:

BACKGROUND: Left ventricular hypertrophy (LVH) occurs as an adaptive response to a physiological (such as exercise) or pathological (valvular disease, hypertension, or obesity) increase in cardiac work. The molecular mechanisms regulating the LVH response are poorly understood. However, inherited defects in fatty acid oxidation are known to cause severe early-onset cardiac hypertrophy. Peroxisome proliferator--activated receptor alpha (PPARalpha) regulates genes responsible for myocardial fa...

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Publication status:
Published

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Publisher copy:
10.1161/hc0802.104535

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Circulation
Volume:
105
Issue:
8
Pages:
950-955
Publication date:
2002-02-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
105055

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