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Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-kappaB and ATF4.

Abstract:

Under anoxia a coordinated, cytoprotective program is induced, called the unfolded protein response (UPR). Activating transcription factor 4 (ATF4) is a mediator of the UPR and activates a gene expression program, promoting tumour growth and survival under anoxia. A key gene induced by ATF4 under normoxic conditions is SKIP3. We characterized the induction of SKIP3 during anoxic exposure to determine whether UPR alone was sufficient or there was a more complex regulatory response to anoxia. T...

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Publication status:
Published

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Publisher copy:
10.1038/onc.2008.100

Authors


Rzymski, T More by this author
Paantjens, A More by this author
Harris, AL More by this author
Journal:
Oncogene
Volume:
27
Issue:
33
Pages:
4532-4543
Publication date:
2008-07-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:107ac8bc-5b64-4b53-a3fa-2a0e26ed39b7
Source identifiers:
125223
Local pid:
pubs:125223

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