Decreased cyclin B1 expression contributes to G2 delay in human brain tumor cells after treatment with camptothecin.

Journal article

DNA damage produces delayed mitosis (G2/M delay) in proliferating cells, and shortening the delay sensitizes human malignant glioma and medulloblastoma cells to cytotoxic chemotherapy. Although activation of the cyclin-dependent kinase CDC2 mediates G2/M transition in all tumor cells studied to date, regulation of CDC2 varies between tumor types. Persistent hyperphosphorylation of kinase and reduced cyclin expression have been implicated as mediators of treatment-induced G2 delay in different...

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Authors: Janss, A; Maity, A; Tang, C; Muschel, R; Mckenna, W

• Publication status: Published
• Journal: Neuro-oncology
• Volume: 3
• Issue: 1
• Pages: 11-21
• Publication date: 2001-01-01
• DOI: 10.1215/s1522851700000259
• EISSN: 1523-5866
• ISSN: 1522-8517
• Language: English
• Keywords: Enzyme Inhibitors; Antineoplastic Agents, Phytogenic; G2 Phase; RNA, Messenger; Cyclin B1; Neoplasm Proteins; Cyclin B; Topoisomerase I Inhibitors; CDC2 Protein Kinase; Brain Neoplasms; Medulloblastoma; Humans; Gene Expression Regulation, Neoplastic; Cyclin A; Glioma; Tumor Cells, Cultured; Camptothecin