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Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione.

Abstract:

Glutathione monoethyl ester (L-gamma-glutamyl-L-cysteinylglycyl ethyl ester), in contrast to glutathione itself, is effectively transported into many types of cells. The ester is converted intracellularly into glutathione. Intraperitoneal injection of 35S-labeled ester into mice was followed by rapid appearance of isotope in the glutathione of liver, kidney, spleen, pancreas, and heart; the glutathione levels of these tissues also increased. Oral administration of the ester to mice also incre...

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Publication status:
Published

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Authors


Anderson, ME More by this author
Meister, A More by this author
Journal:
Archives of biochemistry and biophysics
Volume:
239
Issue:
2
Pages:
538-548
Publication date:
1985-06-05
DOI:
EISSN:
1096-0384
ISSN:
0003-9861
URN:
uuid:106ba50f-98d4-4fda-92df-5c0b9d4e9133
Source identifiers:
23434
Local pid:
pubs:23434

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