OBJECTIVE: Overweight and obesity are associated with a dyslipidaemia which can be improved by weight loss. Whether genetic predisposition to an adverse lipid profile modifies such beneficial effects of weight loss on lipid levels in overweight and obese individuals was examined. DESIGN AND METHODS: White European participants (n = 374) who completed a 12-month weight loss trial were genotyped for 36 lipid-associated single nucleotide polymorphisms (SNPs), previously identified in genome-wide...Expand abstract
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Genetic predisposition to an adverse lipid profile limits the improvement in total cholesterol in response to weight loss.
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