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Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.

Abstract:

Deacetoxycephalosporin C synthase (DAOCS) catalyzes the oxidative ring expansion of penicillin N (penN) to give deacetoxycephalosporin C (DAOC), which is the committed step in the biosynthesis of the clinically important cephalosporin antibiotics. DAOCS belongs to the family of non-heme iron(II) and 2-oxoglutarate (2OG) dependent oxygenases, which have substantially conserved active sites and are proposed to employ a consensus mechanism proceeding via formation of an enzyme·Fe(II)·2OG·substra...

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Publication status:
Published

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Publisher copy:
10.1021/bi500086p

Authors


Tarhonskaya, H More by this author
Szöllössi, A More by this author
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Publisher:
American Chemical Society
Journal:
Biochemistry
Volume:
53
Issue:
15
Pages:
2483-2493
Publication date:
2014-04-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:106827d1-db45-4d89-9d84-7a2198ea5cf6
Source identifiers:
458825
Local pid:
pubs:458825

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