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GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.

Abstract:

Lymphocytes egress from lymphoid organs in response to sphingosine-1-phosphate (S1P); minutes later they migrate from blood into tissue against the S1P gradient. The mechanisms facilitating cell movement against the gradient have not been defined. Here, we show that heterotrimeric guanine nucleotide-binding protein-coupled receptor kinase-2 (GRK2) functions in down-regulation of S1P receptor-1 (S1PR1) on blood-exposed lymphocytes. T and B cell movement from blood into lymph nodes is reduced i...

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Publisher copy:
10.1126/science.1208248

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Science (New York, N.Y.)
Volume:
333
Issue:
6051
Pages:
1898-1903
Publication date:
2011-09-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:105cdf34-cfee-4686-a891-8cdb1b3674d3
Source identifiers:
482824
Local pid:
pubs:482824

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