Journal article
GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.
- Abstract:
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Lymphocytes egress from lymphoid organs in response to sphingosine-1-phosphate (S1P); minutes later they migrate from blood into tissue against the S1P gradient. The mechanisms facilitating cell movement against the gradient have not been defined. Here, we show that heterotrimeric guanine nucleotide-binding protein-coupled receptor kinase-2 (GRK2) functions in down-regulation of S1P receptor-1 (S1PR1) on blood-exposed lymphocytes. T and B cell movement from blood into lymph nodes is reduced i...
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- Publisher copy:
- 10.1126/science.1208248
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Authors
Bibliographic Details
- Journal:
- Science (New York, N.Y.)
- Volume:
- 333
- Issue:
- 6051
- Pages:
- 1898-1903
- Publication date:
- 2011-09-01
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- Source identifiers:
-
482824
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:482824
- UUID:
-
uuid:105cdf34-cfee-4686-a891-8cdb1b3674d3
- Local pid:
- pubs:482824
- Deposit date:
- 2014-09-12
Terms of use
- Copyright date:
- 2011
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