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2.6 Mb YAC contig of the human X inactivation center region in Xq13: physical linkage of the RPS4X, PHKA1, XIST and DXS128E genes.

Abstract:

X chromosome inactivation is a mechanism of dosage compensation that regulates the expression of mammalian X-linked genes between XY males and XX females. This phenomenon is cis-acting, clonally heritable, and requires the presence of an X inactivation center (XIC). In our attempts to characterize this phenomenon, we have focused on the physical organization of the human XIC localized to Xq13. From previous studies, we had determined that the candidate XIC interval contained two loci (DXS128 ...

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Publication status:
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Publisher copy:
10.1093/hmg/2.8.1105

Authors


Lafrenière, RG More by this author
Taillon-Miller, P More by this author
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Journal:
Human molecular genetics
Volume:
2
Issue:
8
Pages:
1105-1115
Publication date:
1993-08-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:105b695f-e405-4418-9f46-2caf6f5c168d
Source identifiers:
44298
Local pid:
pubs:44298

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