A pivotal heme-transfer reaction intermediate in cytochrome c biogenesis.

Journal article

c-Type cytochromes are widespread proteins, fundamental for respiration or photosynthesis in most cells. They contain heme covalently bound to protein in a highly conserved, highly stereospecific post-translational modification. In many bacteria, mitochondria, and archaea this heme attachment is catalyzed by the cytochrome c maturation (Ccm) proteins. Here we identify and characterize a covalent, ternary complex between the heme chaperone CcmE, heme, and cytochrome c. Formation of the complex...

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Authors: Mavridou, D; Stevens, J; Mönkemeyer, L; Daltrop, O; di Gleria, K

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 287
• Issue: 4
• Pages: 2342-2352
• Publication date: 2012-01-01
• DOI: 10.1074/jbc.m111.313692
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Multiprotein Complexes; Cytochromes c; Escherichia coli Proteins; Hemeproteins; Escherichia coli; Heme; Bacterial Outer Membrane Proteins; Protein Biosynthesis