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Reduced expression of the growth hormone and type 1 insulin-like growth factor receptors in human somatotroph tumours and an analysis of possible mutations of the growth hormone receptor.

Abstract:

OBJECTIVE: Clinical acromegaly is characterized by elevated GH secretion in the presence of high circulating IGF-I levels. We hypothesized that the physiological IGF-I/GH negative feedback loop may be reset in somatotroph adenomas, specifically in terms of the level of expression of these receptors or mutations of the GH receptor (GH-R) in such tumours. METHODS: We therefore investigated the full coding sequence of the GH-R in a series of somatotroph and other pituitary adenomas. We also inv...

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Publication status:
Published

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Journal:
Clinical endocrinology
Volume:
59
Issue:
3
Pages:
328-338
Publication date:
2003-09-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:1048fb1d-73c8-4557-b255-21995c6aea87
Source identifiers:
138354
Local pid:
pubs:138354

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