- Abstract:
-
OBJECTIVE: Clinical acromegaly is characterized by elevated GH secretion in the presence of high circulating IGF-I levels. We hypothesized that the physiological IGF-I/GH negative feedback loop may be reset in somatotroph adenomas, specifically in terms of the level of expression of these receptors or mutations of the GH receptor (GH-R) in such tumours. METHODS: We therefore investigated the full coding sequence of the GH-R in a series of somatotroph and other pituitary adenomas. We also inv...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1046/j.1365-2265.2003.01851.x
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- Journal:
- Clinical endocrinology
- Volume:
- 59
- Issue:
- 3
- Pages:
- 328-338
- Publication date:
- 2003-09-05
- DOI:
- EISSN:
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1365-2265
- ISSN:
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0300-0664
- URN:
-
uuid:1048fb1d-73c8-4557-b255-21995c6aea87
- Source identifiers:
-
138354
- Local pid:
- pubs:138354
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Reduced expression of the growth hormone and type 1 insulin-like growth factor receptors in human somatotroph tumours and an analysis of possible mutations of the growth hormone receptor.
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